VU0134992
Kir4.1 blocker / VU0134992 is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM).1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2
Biochemicals & reagents
755002-90-5
1) Kharade (2018), Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker VU0134992; Mol. Pharmacol. 94 926 2) Lu et al. (2022), Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity; Cell. Mol. Life Sci. 79 296
-20°C
TARGET: Ion channel -- PATHWAY: Cation channel -- DISEASE AREA: Hypertension; Kidney disease