Diltiazem
Calcium channel blocker / A non-dihydropyridine-type blocker of L-type Ca2+ channels1,2.Reduces Ca2+ oscillations in subcellular compartments in vascular smooth muscle cells3. Also blocks P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons4. Clinically useful antihypertensive agent5. Cell permeable.
Biochemicals & reagents
33286-22-5
1) Kraus et al. (1998), Molecular mechanism of diltiazem interaction with L-type Ca2+ channels; J. Biol. Chem., 273 27205 2) Godfraind et al. (1986), Calcium antagonism and calcium entry blockade; Pharmacol. Rev., 38 321 3) Fedoryak et al. (2004), Spontaneous Ca2+ oscillations in subcellular compartments of vascular smooth muscle cells rely on different Ca2+ pools; Cell Res., 14 379 4) Ishibashi et al. (1995), Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil; Brain Res., 695 88 5) Chaffman and Bogden (1985), Diltiazem. A review of its pharmacological properties and therapeutic efficacy; Drugs, 29 387
RT
TARGET: Ion channel -- PATHWAY: Calcium signaling -- DISEASE AREA: Hypertension; Heart disease