Minoxidil
KATP channel opener / Minoxidil is a direct antihypertensive peripheral vasodilator acting via activation of KATP channels leading to relaxation of smooth muscle.1 Active metabolite is Minoxidil sulfate (IC50 = 0.14 µM). Mainly used as a treatment for alopecia because of its observed hair regrowth ability.2
Biochemicals & reagents
38304-91-5
1) Meisheri et al. (1988), Mechanism of action of minoxidil sulfate-induced vsodialtion: a role for increased K+ permeability. J.Pharmacol.Exp.Ther., 245 7 / 2) Messenger and Rundegren (2004) Minoxidil:mechanisms of action on hair growth. Br.J.Dermatol. 150 186
RT
TARGET: Ion channel -- PATHWAY: Potassium channel; Autophagy -- RESEARCH AREA: Cell death -- DISEASE AREA: Hypertension; Ageing