UNC-2170 HCl
Methyl-lysine binding protein inhibitor / The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1
Biochemicals & reagents
1648707-58-7
1) Perfetti et al. (2015), Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein 53BP1; ACS Chem. Biol., 10 1072
-20°C
TARGET: DNA -- PATHWAY: DNA repair; Chromatin -- RESEARCH AREA: Epigenetics