2'-Deoxy-5-fluorocytidine
Irreversible DNA methyl transferase inhibitor / A DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors1. Like 5’-Azacytidine and decitabine, 2’-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation2. It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways3. It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo4.
Biochemicals & reagents
10356-76-0
FCDR; FdCyd; NSC-48006; Ro 5-1090
1) Ren et al. (2011), DNA hypermethylation as a chemotherapy target; Cell Signal, 23 1082 2) Gowher et al. (2004), Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy; Cancer Biol. Ther., 3 1062 3) Zhao et al. (2002), Inhibition of cancer cell proliferation by 5-fluoro-2’-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway; Springerplus, 1 65 4) Kumaki et al. (2001), In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections; Antiviral Res., 92 329
-20°C
TARGET: DNA methylation -- PATHWAY: DNA damage; Proliferation; Chromatin -- RESEARCH AREA: Epigenetics -- DISEASE AREA: Cancer; Infectious disease