DUB USP7 inhibitor / Selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM)1,2. Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance1. Displays antiangiogenic activity in vivo2. Cell permeable
Biochemicals & reagents
882257-11-6
1) Chauhan et al. (2012), A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezombi resistance; Cancer Cell, 22 345 2) Weinstock et al. (2012), Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47; ACS Med. Chem. Lett., 3 789
RT
TARGET: DUB (Deubiquitinating enzyme) -- PATHWAY: Degradation; Apoptosis inducer -- RESEARCH AREA: Cell death; Angiogenesis; Ubiquitin/Proteasome -- DISEASE AREA: Cancer