b-AP15 (NSC-687852)
Supplier:
Catalogue number:
10-1340-02
Size:
25 mg
Product is available in:
DUB inhibitor / Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.
Product Type:
Biochemicals & reagents
CAS Number:
1009817-63-3
Alternative Names:
NSC-687852
Reference:
1) D’Arcy, et al. (2011), Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nature Medicine 17 1636
Storage Temperature:
-20°C
Additional Information:
TARGET: DUB (Deubiquitinating enzyme) -- PATHWAY: Degradation; Apoptosis inducer -- RESEARCH AREA: Ubiquitin/Proteasome; Cell death -- DISEASE AREA: Cancer