DUB inhibitor / Inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3). IC50=0.6 µM, 125-fold selective over UCH-L1, IC50=75 µM. Cell permeable.
Product Type:
Biochemicals & reagents
CAS Number:
30675-13-9
Reference:
1) Love et al. (2007), Mechanisms, biology and inhibitors of deubiquitinating enzymes; Nat. Chem. Biol., 3 697 / 2) Mtango et al. (2012), Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation; J. Cell Physiol., 227 2022
Storage Temperature:
RT
Additional Information:
TARGET: DUB (Deubiquitinating enzyme) -- PATHWAY: Degradation -- RESEARCH AREA: Ubiquitin/Proteasome