NSC632839
DUB inhibitor / A pan-specific ubiquitin isopeptidase inhibitor. (IC50= 45, 37 and 9.8 μM for USP2, USP7 and SENP2 respectively) Does not effect proteasome proteolytic activity. Induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway1,2. Cell permeable.
Biochemicals & reagents
157654-67-6
F6
1) Aleo et al. (2006), Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis; Cancer Res., 66 9235 / 2) Nicholson et al. (2008), Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities; Protein Sci. 17 1035
-20°C
TARGET: DUB (Deubiquitinating enzyme) -- PATHWAY: Degradation; Apoptosis inducer; Bcl -- RESEARCH AREA: Ubiquitin/Proteasome; Cell death