WP-1130
DUB inhibitor / A novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Triggers tumor cell apoptosis.1 Blocks Jak2 signaling via Jak2 ubiquitination.2 Causes ablation of the oncogenic transcription factor ERG in prostate cancer cells.3
Biochemicals & reagents
856243-80-6
Degrasyn
1) Kapuria et al. (2010), Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis; Cancer Res., 70 9265 2) Kapuria et al. (2011), A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination; Cell Signal., 23 2076 3) Wang et al. (2014), Ablation of the ocogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer; Proc. Natl. Acad. Sci. USA, 111 4251
-20°C
TARGET: DUB (Deubiquitinating enzyme) -- PATHWAY: Degradation; Apoptosis inducer; JAK/STAT -- RESEARCH AREA: Ubiquitin/Proteasome; Cell death -- DISEASE AREA: Cancer