TGN-020
Aquaporin 4 blocker / Aquaporin 4 channel blocker, IC50 = 3.1 μM.1 Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI.2 Increases regional cerebral blood flow as determined in wild-type and AQP-4 knockout mice.3 Reduces brain edema when administered after onset of ischemia in rat models.4
Biochemicals & reagents
51987-99-6
1) Huber et al. (2009), Identification of aquaporin 4 inhibitors using in vitro and in silico methods; Bioorg. Med. Chem., 17 411 2) Igarashi et al. (2011), Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema; Neurol. Sci., 32 113 3) Igarashi et al. (2013), Inhibition of aquaporin-4 significantly increases regional cerebral blood flow; Infect. Neuroreport, 24 324 4) Pirici et al. (2017), Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways; Int. J. Mol. Sci.; 19 E46
RT
TARGET: Aquaporin -- PATHWAY: Ion channels -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Ischemia