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Apoptolidin

Supplier:
Catalogue number:
10-2950-01
Size:
100 ug
Product is available in:
  • USA
  • Canada
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Apoptosis inducer / Powerful inducer of apoptosis in a variety of cancer cell lines.1 Is believed to act via inhibition of F0F1-ATPase2 but correlation studies indicate that a second mechanism may be the actual mode of action3. Cell permeable.

Product Type:

Biochemicals & reagents

CAS Number:

194874-06-1

Reference:

1) Kim et al. (1997), Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp.; J. Antibiot. (Tokyo), 50 628 2) Salomon et al. (2001), Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase; Chem. Biol., 8 71 3) Wender et al. (2006), Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues; Org. Lett., 8 589

Storage Temperature:

-20°C

Additional Information:

TARGET: ATPase -- PATHWAY: Apoptosis inducer; Warburg effect -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer