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Xanthohumol

Supplier:
Catalogue number:
10-1188-01
Size:
5 mg
Product is available in:
  • USA
  • Canada
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VCP inhibitor / Autophagy inhibitor / Binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II)1. Impairs prostate cancer cell growth and proliferation2. Cell permeable.

Product Type:

Biochemicals & reagents

CAS Number:

6754-58-1

Reference:

1) Sasazawa et al. (2012), Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein; ACS Chem. Biol., 7 892 2) Vene et al. (2012), Xanthohumol impairs prostate cancer cell growth and invasion and dimishes the incidence and progression of advanced tumors in TRAMP mice; Mol. Med., 18 1292

Storage Temperature:

-20°C

Additional Information:

TARGET: ATPase -- PATHWAY: Autophagy; Proliferation -- RESEARCH AREA: Cell death; Vesicles -- DISEASE AREA: Cancer