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PIK-75 hydrochloride

Catalogue number:
SM78-10
Size:
10 mg
Product is available in:
  • USA
  • Canada
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Plerixafor is a bicyclam molecule that antagonizes the binding of the chemokine stromal cell-derived factor-1 (SDF-1) to its cognate receptor CXCR4. The CXCR4 alpha-chemokine receptor and one of its ligands, SDF-1, are important in hematopoietic stem cell homing to the bone marrow and in hematopoietic stem cell quiescence. Plerixafor is one of the most efficient bone marrow stem cell mobilizers. Plerixafor results in the rapid and reversible mobilization of hematopoietic stem cells (HSC) into the peripheral circulation and is synergistic when combined with G-CSF.

Product Type:

Peptides & proteins

CAS Number:

110078-46-1

Alternative Names:

AMD3100, 1,1'-(1,4-Phenylenebis(methylene))bis1,4,8,11-tetraazacyclotetradecane

Range:

1) Uy, GL. 2008. Expert Opin Biol Ther. 8(11): 1797-1804. PMID: 18847313; 2) Kim, JH., et al. 2012. Radiat Res. 178(3): 202-206. PMID: 22799631; 3) Langle, D., et al. 2014. ACS Chem Biol. 9(1): 57-71, PMID: 24372447; 4) Lee, SY., et al. 2014. Amyloid. epub. PMID: 24779777

Limit of Detection:

502.78

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt