Irinotecan hydrochloride trihydrate (CPT 11), a compound within the camptothecin family, is an inhibitor of Topo I (topoisomerase I) involved in cellular DNA replication and transcription. This compound is a prodrug which needs to be transformed by carboxylesterases to its active metabolite SN-38. As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the course of DNA replication which is reported to induce apoptosis or repair mechanisms as a result. Irinotecan has a therapeutic effect in malignant brain tumors, with increased efficacy when combined in neural stem cells therapies.
Peptides & proteins
Camptosar, Topotecin, Campto, Camptothecin 11, CPT-11, CPT 11, U-101440E, PNU-101440E, DQ2805, (S)-4,11-diethyl-4-hydroxy-3,14-dioxo3,4,12,14-tetrahydro-1Hpyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'- bipiperidine]-1'-carboxylate hydrochloride tr
1) Goto, S., et al. 1996. Anticancer Res. 16(5A): 2507-2511. PMID: 8917343; 2) Metz, MZ., et al. 2013. Stem Cells Transl Med. 2(12): 983-992. PMID: 24167321; 3) Hong, SH., et al. 2013. Cancer Gene Ther. 20(12): 678-682. PMID: 24310061
-20°C. Keep away from direct sunlight.
12 months from receipt