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PI-103 hydrochloride

PI-103 hydrochloride
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Size: 10 mg
$155.00
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Catalogue number:
SM76-10
Name:
PI-103 hydrochloride
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Availability:

PIK-75 is a cell-permeable selective inhibitor of PI 3-kinase p110alpha. This molecule inhibits production of PIP2 and PIP3 in adipocytes, phosphorylation of Akt and also activation of mTORC1. It has been studied that PIK-75 significantly reduces leukemia burden and increases the survival of mice engrafted with human acute myeloid leukemia.

Data sheet:

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Product Type:
Peptides & proteins
CAS Number:
372196-77-5
Alternative Names:
PI3-Kinase α Inhibitor VIII, 2-Methyl-5-nitrobenzenesulfonic acid 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide hydrochloride
Storage Temp:
-20°C. Keep away from direct sunlight.
Molecular Weight:
488.74
Material Safety Data Sheet:
Reference:
1) Kingham, E. and Welham, M. 2009. J Cell Sci. 122:2311-2321. PMID: 19509054; 2) Yi, YW., et al. 2013. Mol Carcinog. 52(9): 667-675. PMID: 22488590; 3) Thomas, D., et al. 2013. Blood. 122(5): 738-748. PMID: 23775716
Shelf Life:
12 months from receipt