PIK-75 is a cell-permeable selective inhibitor of PI 3-kinase p110alpha. This molecule inhibits production of PIP2 and PIP3 in adipocytes, phosphorylation of Akt and also activation of mTORC1. It has been studied that PIK-75 significantly reduces leukemia burden and increases the survival of mice engrafted with human acute myeloid leukemia.
Peptides & proteins
PI3-Kinase α Inhibitor VIII, 2-Methyl-5-nitrobenzenesulfonic acid 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide hydrochloride
1) Kingham, E. and Welham, M. 2009. J Cell Sci. 122:2311-2321. PMID: 19509054; 2) Yi, YW., et al. 2013. Mol Carcinog. 52(9): 667-675. PMID: 22488590; 3) Thomas, D., et al. 2013. Blood. 122(5): 738-748. PMID: 23775716
-20°C. Keep away from direct sunlight.
12 months from receipt