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BIX01294 Trihydrochloride Hydrate 

Catalogue number:
SM12-50
Size:
50 mg
Product is available in:
  • USA
  • Canada
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BIX01294 is a G9a-like protein and G9a histone lysine methyltransferase inhibitor (IC50 values are 0.7 and 1.7 μM, respectively) that displays no activity at other histone methyltransferases up to 37 μM. BIX01294 modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in-vitro.

Product Type:

Peptides & proteins

CAS Number:

1392399-03-9

Alternative Names:

BIX 01294, BIX-01294, 2-(Hexahydro-4-methyl-1H-1, 4-diazepin-1-yl)-6, 7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride

Range:

1) Tachibana, M., et al., 2002. Genes Dev. 16(14): 1779-1791. PMID: 12130538; 2) Wagschal, A., et al. 2008. Mol Cell Biol. 28(3) 1104-1113. PMID: 18039842; 3) Thomas, L.R., et al. 2008. J Immunol. 181(1): 485-493. PMID: 18566414; 4) Kubicek, S., et al. 2007. Mol Cell. 25(3): 473-481. PMID: 17289593 5. Shi, Y., et al. 2008. Cell Stem Cell. 3(5): 568-574. PMID: 18983970

Limit of Detection:

600.02

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt