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ProTx-I (ATTO488)

Catalogue number:
PTF003-00500
Size:
500 µg
Product is available in:
  • USA
  • Canada
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ATTO488-ProTx-I is a fluorescently labeled peptide. Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8 (IC50 = 27 nM) and TTX sensitive Nav channels such Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation.

  • Applications:TARGET CLASS: Sodium channel; TARGET: Nav1.8; ACTION: Fluorescent blocker
Product Type:

Peptides & proteins

Alternative Names:

Protoxin I; ProTx 1

Storage Temperature:

RT

Additional Information:

AA SEQUENCE: Glu-Cys2-Arg-Tyr-Trp-Leu-Gly-Gly-Cys9-Ser-Ala-Gly-Gln-Thr-Cys15-Cys16-Lys-His-Leu-Val-Cys21-Ser-Arg-Arg-His-Gly-Trp-Cys28-Val-Trp-Asp-Gly-Thr-Phe-Ser-OH; DISULFIDE BRIDGES: Cys2-Cys16, Cys9-Cys21, Cys15-Cys28; SOURCE: Synthetic; PURITY: > 95%; ATTO488: λex 500nm , λem 520nm