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GsAF-II

GsAF-II
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Size: 1.0 mg
$1385.00
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Catalogue number:
12GSF002-01000
Name:
GsAF-II
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GsAF-II (also termed Kappa-theraphotoxin-Gr2c) was originally isolated from the venom of Grammostola rosea spider. This peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with IC50 values of, respectively, 5.7, 12, 24, 4, 6.6 and 1.3 µM. This peptide also blocks hERG1 with an IC50 value of 4.7 µM.

Product Type:
Peptides & proteins
Storage Temp:
RT
Molecular Weight:
3979.78 Da
Reference:
Elisa Redaelli, et al. (2010) Target Promiscuity and Heterogeneous Effects of Tarantula Venom Peptides Affecting Na+ and K+ Ion Channels. JBC.