life science research products, biological research products, biotechnology
Use * as wildcard:
iclines
RNAStorm
Pluripro

ProTx II (Biotin)

ProTx II (Biotin)
print page
Size: 0.1 mg
$510.00
Add to basket
Catalogue number:
12PTB002-00100
Name:
ProTx II (Biotin)
Supplier:
Availability:

Protoxin II is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula). Protoxin II inhibits voltage-gated calcium and sodium channels (site 4). This toxin inhibits activation by shifting the voltage-dependence of channel activation to more positive potentials. The toxin potently inhibits all sodium channel subtypes tested (Nav1.2/SCN2A, Nav1.5/SCN5A, Nav1.7/SCN9A, and Nav1.8/SCN10A). It is approximately 15-fold more potent on Nav1.7/SCN9A than on Nav1.5/SCN5A channels and acts on Cav3.1/CACNA1G and interacts more weakly with the related T-Type channel Cav3.2/CACNA1H but potently inhibits the L-type calcium channel Cav1.2/CACNA1C. Protoxin II also binds to phospholipids. ProTx-II, a selective inhibitor of Nav1.7 sodium channels, blocks action potential propagation in nociceptors.

Product Type:
Peptides & proteins
Alternative Names:
Protoxin II
Storage Temp:
RT
Molecular Weight:
4052.74 Da
Reference:
Edgerton, G. B., et al. (2008) Toxicon; Smith, J. J., (2005) J Biol Chem