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μ-conotoxin PIIIA

μ-conotoxin PIIIA
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Size: 0.5 mg
$583.00
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Catalogue number:
08CON006-00500
Name:
μ-conotoxin PIIIA
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μ-conotoxin PIIIA has been isolated from the venom of the cone Conus purpurascens. μ-conotoxins bind and block site 1 of voltage-gated sodium channels. This toxin blocks the neuronal sodium channels Nav1.2 (SCN2A) and Nav1.7 (SCN9A). The peptide causes flaccid paralysis in both mice and fish.

Product Type:
Peptides & proteins
Storage Temp:
RT
Molecular Weight:
2604.10 Da
Reference:
Nielsen, K. J., et al. (2002) Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels, J Biol Chem; Safo, P., et al. (2000) Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA, J Neurosci; Shon, K. J., et al. (1998) mu-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes, J Neurosci