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PD173074

Supplier:
Catalogue number:
10-4505-01
Size:
5 mg
Product is available in:
  • USA
  • Canada
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FGFR inhibitor / Inhibitor of FGFR tyrosine kinase, and to a lesser extent VEGFR1 (IC50 values are 5 nM, 22.5 nM and 100 nM for FGFR1, FGFR3 and VEGFR respectively). Inhibition of FGFR promotes stem sell self renewal.2,3

Product Type:

Biochemicals & reagents

CAS Number:

219580-11-7

Reference:

1)     Bansal et al. (2003), Specific inhibitor of FGF receptor signaling: FGF-2 mediated effects on proliferation, differentiation and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells; J. Neurosci. Res., 74 486 2) Kim et al. (2012), Regulation of autocrine fibroblast growth factor-2 signaling by perfusion flow in 3D human mesencymal stem cell constructs; Biotechnol. Prog., 28 1384 3) Zaragosi et al. (2006), Autocrine fibroblast growth factor 2 signaling is critical for self renewal of human multipotent adipose-derived stem cells; Stem Cells, 24 2412

Storage Temperature:

-20°C

Additional Information:

TARGET: Kinase -- PATHWAY: MAPK -- RESEARCH AREA: Stem cells -- DISEASE AREA: Cancer