PD173074
FGFR inhibitor / Inhibitor of FGFR tyrosine kinase, and to a lesser extent VEGFR1 (IC50 values are 5 nM, 22.5 nM and 100 nM for FGFR1, FGFR3 and VEGFR respectively). Inhibition of FGFR promotes stem sell self renewal.2,3
Biochemicals & reagents
219580-11-7
1) Bansal et al. (2003), Specific inhibitor of FGF receptor signaling: FGF-2 mediated effects on proliferation, differentiation and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells; J. Neurosci. Res., 74 486 2) Kim et al. (2012), Regulation of autocrine fibroblast growth factor-2 signaling by perfusion flow in 3D human mesencymal stem cell constructs; Biotechnol. Prog., 28 1384 3) Zaragosi et al. (2006), Autocrine fibroblast growth factor 2 signaling is critical for self renewal of human multipotent adipose-derived stem cells; Stem Cells, 24 2412
-20°C
TARGET: Kinase -- PATHWAY: MAPK -- RESEARCH AREA: Stem cells -- DISEASE AREA: Cancer