SU-5402
FGFR Phosphorylation inhibitor / Inhibits FGFR phosphorylation in vitro, in cell culture1, and in mouse tumor cell models2. SU-5402 can suppress ECP induced cardiomyocyte differentiation of P19CL6 embryonic carcinoma cells via an FGFR3 dependent pathway3.
Biochemicals & reagents
215543-92-3
PF-02969207
1) Lee et al. (2013), Interleukin-1β enhances cell migration through AP-κ1 and NF-B pathway dependent FGF2 expression in human corneal endothelial cells; Biol. Cell, epub ahead of print Jan. 18 2013 2) Paterson et al. (2004), Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma; Br. J. Haematol., 124 595 3) Jin et al. (2012), Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulation the FGF receptor signaling pathway; Growth Factors, 30 344
-20°C
TARGET: Kinase -- PATHWAY: MAPK -- RESEARCH AREA: Stem cells -- DISEASE AREA: Cancer