PD-98059
MEK inhibitor / Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts via binding to the inactivated form of MEK, preventing its phosphorylation by cRAF or MEK kinase (IC50=2-7uM).1,2 Accelerates differentiation of RAW264.7 cells into osteoclast-like cells.3 Mimics BMP4 in supporting self renewal of embryonic stem cells4.
Biochemicals & reagents
167869-21-8
2’-Amino-3’-methoxyflavone
1) Alessi et al. (1995), PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo; J. Biol. Chem., 270 27489 2) Dudley et al. (1995), A synthetic inhibitor of the mitogen-activated protein kinase cascade; Proc. Natl. Acad. Sci., 92 7686 3) Hotokezaka et al. (2002) U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells; J. Biol. Chem., 277 47366 4) Xiaoxia et al. (2004) BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways; Proc. Natl. Acad. Sci. USA 101 6027
RT
TARGET: Kinase -- PATHWAY: Proliferation; PI3K; ERK -- RESEARCH AREA: Stem cells -- DISEASE AREA: Cancer