Cercosporin
ROS-generating fungal toxin / Perylenequinone from the fungus Cercospora kikuchii. Upon photo-activation, perylenequinones display almost universal toxicity to a broad variety of organisms.1 Exposure to visible and near-UV light activates this family of quinones to an excited triplet state that reacts with oxygen to form reactive oxygen species.2 Displays antiproliferative effects in various tumor cell lines.3 Selectively inhibits PKC (IC50=0.6-1.3 mM) over PKA and PPK.4
Biochemicals & reagents
35082-49-6
NSC-153111
1 Daub et al. (2013), Reactive oxygen species in plant pathogenesis: the role of perylenequinone photosensitizers; Antioxid. Redox. Signal 19 970 2 Guedes and Eriksson (2007), Photophysics, photochemistry, and reactivity: molecular aspects of perylenequinone reactions, Photochem. Photobiol. Sci. 6 1089 3 Vandenbogaerde et al. (1998), Cytotoxicity and antiproliferative effect of hypericin and derivatives after photosensitization; Photochem. Photobiol., 67 119 4 Morgan et al. (2009), Design, Synthesis, and Investigation of Protein Kinase C Inhibitors: Total Syntheses of (+)-Calphostin D, (+)-Phleichrome, Cercosporin, and New Photoactive Perylenequinones; J. Am. Chem. Soc., 131 9413
-20°C
TARGET: Kinase -- PATHWAY: Cytotoxicity -- RESEARCH AREA: Oxidative stress; Cell death -- DISEASE AREA: Cancer