Dofetilide
Supplier:
Catalogue number:
10-1151-01
Size:
10 mg
Product is available in:
Herg channel blocker / Dofetilide is a clinically useful class III antiarrhythmic that inhibits the rapid component of the delayed rectifier outward potassium current (IKr) via selective blockage of the Kv11.1 (hERG) channel.1,2
Product Type:
Biochemicals & reagents
CAS Number:
115256-11-6
Alternative Names:
Tikosyn
Reference:
1) Gwilt, et al., (1991) UK-68,798: a novel, potent and highly selective classIII antiarrhythmic agent whci blocks potassium channels in cardiac cells; J.Pharmacol.Exp.Ther. 256 318 / 2) Snyders and Chaudhary, (1996) High affinity open channel block by dofetilide of HERG expressed in a human cell line; Mol.Pharmacol. 49 949
Storage Temperature:
RT
Additional Information:
TARGET: Ion channel -- PATHWAY: Potassium channel