A1899
Supplier:
Catalogue number:
10-4656-02
Size:
25 mg
Product is available in:
Potent and selective K2P3.1 blocker / A1899 is a potent and selective blocker of the two-pore domain potassium channels K2P3.1 (TASK-1; IC50 = 7 nM) and K2P9.1 (TASK-3; IC50 = 70 nM).1 It stimulated breathing in isoflurane-anesthetized rats.2
Product Type:
Biochemicals & reagents
CAS Number:
498577-46-1
Reference:
1) Streit et al. (2011), A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the the TASK-1 Open Pore; J. Biol. Chem. 286 13977 2) Choski et al. (2015), Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore; Mol. Pharmacol. 88 926
Storage Temperature:
-20°C
Additional Information:
TARGET: Ion channel -- PATHWAY: Cation channel; Calcium signaling