NS 1619
Selective KCa1.1 activator / NS 1619 is a selective activator of large conductance Ca(2+)-dependent potassium channels (BKCa or KCa1.1).1,2 It was able to increase blood-brain tumor barrier permeability in rat brain tumor models.3,4 NS 1619 inhibited proliferation and induced apoptosis in A2780 ovarian cancer cells.5 Displays cardioprotective effects in an ischemia-reperfusion model6 and neuroprotective effects in a traumatic brain injury model7.
Biochemicals & reagents
153587-01-0
1) Olesen et al. (1994), Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone; Eur. J. Pharmacol. 251 53 2) Sellers and Ashford (1994), Activation of BKCa channels in acutely dissociated neurons from the rat ventromedial hypothalamus by NS 1619; Br. J. Pharmacol. 113 659 3) Ningaraj et al. (2002), Regulation of blood-brain tumor barrier permeability by calcium-activated potassium channels; J. Pharmacol. Exp. Ther. 301 838 4) Ningaraj et al. (2009), Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model; Cancer Biol. Ther. 8 1924 5) Han et al. (2008), The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells; Biochem. Biophys. Res. Commun. 375 205 6) Dai et al. (2017), Preconditioning with the BKCa channel activator NS-1619 prevents ischemia-reperfusion-induced inflammation and mucosal barrier dysfunction: roles for ROS and heme oxygenase-1; Am. J. Physiol. Heart Circ. Physiol. 313 H988 7) Gao et al. (2022), NS1619 Alleviate Brain-Derived Extracellular Vesicle-Induced Brain Injury by Regulating BKCa Channel and Nrf2/HO-1/NK-kB Pathway; Oxid. Med. Cell Longev. 2022 2257427
-20°C
TARGET: Ion channel -- PATHWAY: Cation channel; Proliferation; Calcium signaling -- DISEASE AREA: Heart disease; CancerIschemia