Flecainide acetate
Sodium channel blocker / Open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner.1 Orally-active class Ic antiarrhythmic agent.2,3 Inhibits hERG potassium channels at clinically relevant concentrations.4
Biochemicals & reagents
54143-56-5
1) Rouet and Ducouret (1994), Use- and concentration-dependent effects of flecainide in guinea pig right ventricular muscle; J. Cardiovasc. Pharmacol., 24 177 2) Singh et al. (1984), The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions; Ann. N.Y. Acad. Sci., 432 210 3) Banitt et al. (1977), Anti-arrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides; J. Med. Chem., 20 821 4) Melgari et al. (2015), Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide; J. Mol. Cell. Cardiol., 86 42
-20°C
TARGET: Ion channel -- PATHWAY: Sodium channel; Calcium signaling -- DISEASE AREA: Heart disease