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Ranolazine

Supplier:
Catalogue number:
10-3701-01
Size:
10 mg
Product is available in:
  • USA
  • Canada
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Selective sodium channel blocker / Ranolazine is an FDA-approved drug used for the treatment of chronic angina. It inhibits the late inward sodium current in heart muscle leading to decreased intracellular calcium levels.1 It blocks Nav 1.4, 1.5, 1.7 and 1.8 (IC50’s = 2.42, 6.22, 1.72(10.33), 21.53 µM respectively.

Product Type:

Biochemicals & reagents

CAS Number:

142387-99-3

Reference:

1) Belardinelli, et al., (2006), Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine; Heart 92 iv6 2) Wang, et al. (2008), State- and Use-Dependent Block of Muscle Nav1.4 and Neuronal Nav1.7 Voltage-Gated Na+-Channel Isoforms by Ranolazine; Mol. Pharmacol. 73 940 3) Rajamani, et al., (2008), Block of tetrodotoxin-sensitive, Na(V)1.7 and tetrodotoxin-resistant, Na(V)1.8, Na+ channels by ranolazine; Channels(Austin) 2 449

Storage Temperature:

RT

Additional Information:

TARGET: Ion channel -- PATHWAY: Calcium signaling; Sodium channel -- DISEASE AREA: Heart disease; Diabetes