DMAPT
NFκB inhibitor / A water soluble analog of the natural plant product parthenolide which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits NFB and stimulates the formation of reactive oxygen species which induced the activation of JNK1. In non-small cell lung cancers it inhibits NFB and DNA double-strand break repair2.
Biochemicals & reagents
870677-05-7
1) Shanmugam et al. (2011), A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NFkB and generating reactive oxygen species; Int. J. Cancer, 128 2481 2) Estrabrook et al. (2011), Inhibition of NF-kB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays; Free Radic. Biol. Med., 51 2249
-20°C
TARGET: Glutathione -- PATHWAY: NFkappaB; Redox; JNK pathway; Cytokine -- RESEARCH AREA: Cell death; Oxidative stress -- DISEASE AREA: Cancer