GPX4 inhibitor / Ferroptosis inducer / RSL3 inhibits glutathione peroxidase (GPX4) inducing ferroptosis.1,2 Effectively induces ferroptosis in glioblastoma cells.3 Everolimus in combination with RSL3 synergistically inhibits the viability of renal cell carcinoma (RCC) cells suggesting a mechanism by which RCC drug resistance may be overcome.4
Biochemicals & reagents
1219810-16-8
1S,3R-RSL3
Yang et al. (2014), Regulation of ferroptotic cancer cell death by GPX4; Cell 156 317 Kagan et al. (2017), Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis; nAT. Chem. Biol. 13 81 Shengbiao et al. (2021), RSL3 Drives Ferroptosis through NF-kB Pathway Activation and GPX4 depletion in Glioblastoma; oXID. Med. Cell. Longev. 2021 2915019 Yangyun et al. (2022), Everolimus accelerates Erastin and RSL3-induced ferroptosis in renal cell carcinoma; Gene 809 145992
-20°C
TARGET: Glutathione -- PATHWAY: Ferroptosis; Mitochondrial function; Redox; NFkappaB -- RESEARCH AREA: Oxidative stress; Cell death; Neuroscience -- DISEASE AREA: Cancer