Fasentin
Glucose uptake inhibitor / A novel inhibitor of glucose uptake which acts via inhibition of the glucose transporter GluT1 and GluT4 (IC50=68 uM).1 Inhibition of glucose uptake is cell type specific2 and is a promising approach to new cancer therapeutics3. Rescues cardiac progenitor cell dysfunction and mitochondrial fission induced by high glucose4. Sensitizes cells to FAS-induced cell death.5,6
Biochemicals & reagents
392721-37-8
1) Granchi et al. (2016), Anticancer agents interacting with membrane glucose transporters; Med. Chem. Comm., 7 1716 2) Kraus et al. (2018), targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation; Cell. Oncol. (Dordr), 41 485 3) Adekola et al. (2012), Glucose transporters in cancer metabolism; Curr. Opin. Oncol., 24 650 4) Choi et al. (2016), High Glucose Causes Human Cardiac Progenitor Cell Dysfunction by Promoting Mitochondrial Fission: Role of a GLUT1 Blocker; Prog. Biomol. Ther. (Seoul), 24 363 5) Schimmer et al. (2006), Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factot-family death receptors; Cancer Res., 66 2367 6) Wood et al. (2008), A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death; Mol. Cancer Ther., 7 3546
RT
TARGET: Glucose transporter -- PATHWAY: Mitochondrial function; Carbohydrate metabolism; Proliferation; Warburg effect -- RESEARCH AREA: Cell death; Angiogenesis; Oxidative stress -- DISEASE AREA: Heart disease; DiabetesCancer