5-Thio-D-glucose
Glucose transport inhibitor / A potent competitive inhibitor of the cellular transport of glucose and glucose-mediated insulin release.1 May be used to induce a state of glucose deprivation in laboratory animals.2 Stimulates feeding in rat models.3 Induces Alzheimer-like changes in frontal cortex and hippocampus in rats.4 Elevates renal TGF-1 at a dose that does not prevent streptozotocin diabetes in rats.5
Biochemicals & reagents
20408-97-3
5TG
1) Wang et al. (1995) Glucose transporter 2 expression: prevention of streptozotocin-induced reduction in beta-cells with 5-thio-D-glucose; Exp. Clin. Endocrinol. Diabetes, 103 83 Suppl.2 2) Shah et al. (2019), Recurrent glucose deprivation leads to the preferential use of lactate by neurons in the ventromedial hypothalamus; Am. J. Physiol. Endocrinol. Metab., 316 E948 3) Li et al. (2014), Stimulation of feeding by three different flucose-sensing mechanisms requires hindbrain catecholamine neurons; Am. J. Physiol. Regul. Integr. Comp. Physiol., 306 R257 4) Salkovic-Petrisic et al. (2006), Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway; J. Neurochem., 96 1005 5) Lane et al. (2000), 5-thio=D-glucose elevates renal transforming growth factor beta-1 at a dose that does not prevent streptozocine diabetes in rats; Am. Endocrinology, 141 3337
RT
TARGET: Glucose transporter -- PATHWAY: Carbohydrate metabolism; DNA damage -- RESEARCH AREA: Oxidative stress; Neuroscience -- DISEASE AREA: Diabetes; CancerObesity; Neurodegeneration