Neuroprotective / P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity.1 Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis.2 Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson disease.3 Restores hippocampal neurogenesis in a mouse model of Down Syndrome.4 The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD.5 Active in vivo.
Biochemicals & reagents
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1) Pieper et al. (2010), Discovery of a proneurogenic, neuroprotective chemical; Cell, 142 39 2) Tesla et al. (2012), Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis; Proc. Natl. Acad. Sci. USA, 109 17016 3) De Jesus-Cortes et al. (2012), Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease; Proc. Natl. Acad. Sci. USA, 109 17010 4) Latchney et al. (2015), Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome; Neurosci. Lett. 591 86 5) Wang et al. (2014), P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage; Cell, 158 1324
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TARGET: Energy production -- PATHWAY: NAD, NADP pathways; Apoptosis inhibitor -- RESEARCH AREA: Neuroscience; Cell death; Stem cells -- DISEASE AREA: Neurodegeneration