FK-866 HCl
Supplier:
Catalogue number:
10-1109-02
Size:
25 mg
Product is available in:
NAD biosynth inhibitor / Nicotinamide phosphoribosyltransferase inhibitor (Ki=0.4 nM). Induces tumor cell apoptosis. Extends lifespan of human cells. Cell permeable.
Product Type:
Biochemicals & reagents
CAS Number:
658084-64-1
Reference:
1) Hasmann et al. (2003), FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis; Cancer Res., 63 7436 / 2) Van der Veer et al. (2007), Extension of human cell lifespan by nicotinamide phosphoribosyltransferase; J. Biol. Chem., 282 10841
Storage Temperature:
-20°C
Additional Information:
TARGET: Energy production -- PATHWAY: NAD, NADP pathways; Apoptosis inducer; Autophagy; Chromatin -- RESEARCH AREA: Epigenetics; Cell death