P7C3-A20
NAMPT activator / Proneurogenic agent / P7C3-A20 is a neuroprotective and proneurogenic agent acting via NAMPT stimulation.1 Displays neuroprotective and promotes endogenous reparative functions after traumatic brain injury (TBI).2 Furthermore it repairs the blood-brain barrier, arrests chronic neurodegeneration and restores cognition after TBI in a mouse model.3 P7C3-A20 exerts neuroprotective effects in a hypoxic-ischemic encephalopathy model.4 Suppresses neuroinflammation and protects retinal ganglion cells from optic nerve crush in a rat model.5
Biochemicals & reagents
1235481-90-9
1 LoCoco et al. (2017), Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy; Elife, 6 e29626 2 Blaya et al. (2014), Neuroprotective efficacy of a proneurigenic compound after traumatic brain injury; Neurotrauma, 31 476 3 Vázquez-Rosa et al. (2020), P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition; Proc. Natl. Acad. Sci. USA, 117 27667 4 Bai et al. (2020), The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic-ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3ß Signaling; Neuroscience, 441 197 5 Oku et al. (2017), P7C3 Suppresses Neuroinflammation and Protects Retinal Ganglion Cells of Rats from Optic Nerve Crush; Invest. Ophthamol. Vis. Sci., 58 4877
-20°C
TARGET: Energy production -- PATHWAY: NAD, NADP pathways -- RESEARCH AREA: Neuroscience; Cell death; Stem cells -- DISEASE AREA: Neurodegeneration