Mre11-Rad50-Nbs1 inhibitor / Mirin is an inhibitor of the Mre11-Rad50-Nbs1(MRN) complex (IC50 = 12 µM for inhibition of ATM activity), part of the MRN-ATM(ataxia-telangiectasia mutated) pathway, an essential pathway for sensing and signaling from DNA double-strand breaks. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells.
Product Type:
Biochemicals & reagents
CAS Number:
299953-00-7
Reference:
1) Dupre et al. (2008), A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex; Nat.Chem.Biol., 4 119.
Storage Temperature:
-20°C
Additional Information:
TARGET: DNA -- PATHWAY: Cell cycle; DNA damage; DNA repair -- DISEASE AREA: Cancer