8-Oxo-2'-deoxyguanosine
Marker for DNA damage / A useful marker for DNA damage via a variety of oxidative processes1. It is a critical biomarker for oxidative stress and carcinogenesis2,3.
Biochemicals & reagents
88847-89-6
8-Oxo-dG; Oxo-dG
1) Beckman et al. (1997), Oxidative decay of DNA; J. Biol. Chem., 272 19636 2) Andreoli et al. (2010), Quantitative determination of urinary 8-oxo-7,8-dihydro-2’-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroquanosine, and their non-oxidized forms: daily concentration profile for healthy volunteers; Biomarkers, 15 221 3) Manini et al. (2009), Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers; Toxicol. Lett., 190 41
-20°C
TARGET: DNA -- PATHWAY: DNA damage -- RESEARCH AREA: Oxidative stress -- DISEASE AREA: Cancer