Temozolomide
Autophagy inducer / DNA alkylating agent with antitumor and antiangiogenic activity1,2. Clinically useful anticancer agent3. Induces autophagy in a variety of cell lines4. Cell permeable.
Biochemicals & reagents
85622-93-1
NSC-362856
1) Kurzen et al. (2003), Inhibition of angiogenesis by non-toxic doses of temozolomide; Anticancer Drugs, 14 515 2) Gunther et al. (2003), Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids; Br. J. Cancer, 88 463 3) Danson et al. (2001), Temozolomide: a novel oral alkylating agent; Curr. Opin. Expert Rev. Anticancer Ther., 10 13 4) Natsumeda et al. (2011), Induction of autophagy in temozolomide treated malignant gliomas; Neuropathology, 31 486
-20°C
TARGET: DNA -- PATHWAY: DNA damage; Autophagy -- RESEARCH AREA: Angiogenesis; Cell death -- DISEASE AREA: Cancer