iGP-1
Mitochondrial GPDH inhibitor / A potent and cell permeable inhibitor of the mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), IC50=6.3 uM, which is selective over the cytosolic enzyme1. It does not block pyruvate uptake into cells or mitochondria and has no direct effect on glycolysis in synaptosomes. This novel inhibitor is a unique tool which may be used to investigate the role of glycerol-3-phosphate metabolism in isolated and intact systems.1
Biochemicals & reagents
27031-00-1
1) Orr et al. (2014), Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase; PLoS One, 9 e89938
-20°C
TARGET: Dehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, KGDH, PDH, and MDH) -- PATHWAY: Apoptosis inducer; Mitochondrial function -- RESEARCH AREA: Cell death -- DISEASE AREA: Diabetes; Cancer