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Celecoxib

Supplier:
Catalogue number:
10-2124-01
Size:
50 mg
Product is available in:
  • USA
  • Canada
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COX II inhibitor / Selective inhibitor of cyclooxygenase-2 (COX-2) IC50 = 15 and 0.04 mM for COX-1 and COX-2 respectively1. Potent and clinically useful antiinflammatory agent2. Cancer chemopreventive agent3. May act synergistically with currently used anticancer agents4. Cell permeable, active in vivo.

Product Type:

Biochemicals & reagents

CAS Number:

169590-42-5

Alternative Names:

SC-58635

Reference:

1) Penning et al. (1997), Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib); J. Med. Chem., 40 1347 2) DeWitt et al. (1999), Cox-2-selective inhibitors: the new super aspirins; Mol. Phamracol., 55 625 3) Harris et al. (2000), Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor; Cancer Res., 60 2101 4) Koki and Masferrer et al. (2002), Celecoxib: a specific COX-2 inhibitor with anticancer properties; Cancer Control, 9 28

Storage Temperature:

RT

Additional Information:

TARGET: COX (Cyclooxygenase) -- DISEASE AREA: Cancer; Inflammation