SC-560
Selective COX-1 inhibitor / SC-560 is a highly selective (700-fold selective over COX-2) and potent (IC50 = 9 nM) inhibitor of cyclooxygenase-1(COX-1).1 SC-560 inhibited TNFa-induced PGE2 synthesis in neurons and, PGE2 and thromboxane A2 synthesis in human monocytes and platelets (IC50’s = 1.8 nM and 2.5 nM respectively) indicating non-selective COX inhibition. SC-560 was able to inhibit PGE2 synthesis in COX-1-deficient neurons indicating a COX-1 independent mechanism. This unselective COX inhibition was only observed in whole cells – it remained COX-1 specific in cell lysates.2
Biochemicals & reagents
188817-13-2
1) Smith et al. (1998), Pharmacological analysis of cyclooxygenase-1 in inflammation; Proc.Natl.Acad.Sci.USA 95 13313 2) Brenneis et al. (2006), Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition; FASEB J. 20 1352
-20°C
TARGET: COX (Cyclooxygenase) -- PATHWAY: Coagulation -- DISEASE AREA: Inflammation