Celecoxib
COX II inhibitor / Selective inhibitor of cyclooxygenase-2 (COX-2) IC50 = 15 and 0.04 mM for COX-1 and COX-2 respectively1. Potent and clinically useful antiinflammatory agent2. Cancer chemopreventive agent3. May act synergistically with currently used anticancer agents4. Cell permeable, active in vivo.
Biochemicals & reagents
169590-42-5
SC-58635
1) Penning et al. (1997), Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib); J. Med. Chem., 40 1347 2) DeWitt et al. (1999), Cox-2-selective inhibitors: the new super aspirins; Mol. Phamracol., 55 625 3) Harris et al. (2000), Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor; Cancer Res., 60 2101 4) Koki and Masferrer et al. (2002), Celecoxib: a specific COX-2 inhibitor with anticancer properties; Cancer Control, 9 28
RT
TARGET: COX (Cyclooxygenase) -- DISEASE AREA: Cancer; Inflammation