SGC-iMLLT

Name: SGC-iMLLT
Brand: Focus Biomolecules
SKU: 10-4046-01
Price: 75 GBP
Availability: InStock

Supplier:

Focus Biomolecules

Catalogue number:

10-4046-01

Size:

5 mg

Product is available in:

$75.00

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MLLT1/3 YEATS domain inhibitor / Potent (IC50 = 260 nM) inhibitor of the YEATS domain of MLLT1/3.1 YEATS domain containing proteins bind acetyl and crotonyl marks on histone tails. Selective against the two other human YEATS domains YEATS2/4 and 48 bromodomains. YEATS containing MLL-ENL leukemic cells display increased sensitivity to SGC-iMLLT versus control AML cells.2

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Product Type:

Biochemicals & reagents

CAS Number:

2255338-25-9

Reference:

1) Moustakim et al. (2018) Discovery of an MLLT1/3 YEATS Domain Chemical Probe; Angew. Chem. Int. Eng. Ed. 57 16302 2) Hu et al. (2022) The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia; Leukemia Online ahead of print

Storage Temperature:

-20°C

Additional Information:

TARGET: Bromodomain -- PATHWAY: Chromatin; Posttranslational modification -- RESEARCH AREA: Epigenetics -- DISEASE AREA: Cancer