www.mayflowerbio.com
Sales & Support: 314-485-5210

*

BI-9564

Supplier:
Catalogue number:
10-4320-01
Size:
5 mg
Product is available in:
  • USA
  • Canada
$60.00 Shipping is calculated in checkout

BRD9 bromodomain inhibitor / Potent, selective, and cell permeable inhibitor of the BRD9 bromodomain, a subunit of the switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex (IC50 = 75 nM).1 It displayed antitumor activity in an acute myeloid leukemia xenograft model. BI-9564 displayed cytotoxic and anti-proliferative effects in 5 rhabdoid tumor cell lines.2

Product Type:

Biochemicals & reagents

CAS Number:

1883429-22-8

Reference:

1) Martin et al. (2016), Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor; J. Med. Chem., 59 4462 2) Krämer et al. (2017), BRD9 Inhibition, Alone or in Combination with Cytostatic Compounds as a Therapeutic Approach in Rhabdoid Tumors; Int. J. Mol. Sci., 18 1537

Storage Temperature:

-20°C

Additional Information:

TARGET: Bromodomain -- PATHWAY: Chromatin; Posttranslational modification -- RESEARCH AREA: Epigenetics -- DISEASE AREA: Cancer