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AT-101

Supplier:
Catalogue number:
10-1165-02
Size:
50 mg
Product is available in:
  • USA
  • Canada
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Bcl-2 inhibitor / A small molecule mimic of the BH3 domain of cellular Bcl-2 inhibitors which interferes with the function of Bcl-2-family antiapoptotic proteins. Induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway. Cell permeable.

Product Type:

Biochemicals & reagents

CAS Number:

90141-22-3

Alternative Names:

R(-)-Gossypol

Reference:

1) Kline et al. (2008), R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells.; Exp. Hematol., 36 568 / 2) Balakrishnan et al. (2009), AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance.; Blood, 113 149

Storage Temperature:

-20°C

Additional Information:

TARGET: Bcl-2 -- PATHWAY: Apoptosis inducer; Mitochondrial function; Bcl -- RESEARCH AREA: Cell death