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αC-conotoxin PrXA

αC-conotoxin PrXA
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Size: 0.5 mg
$510.00
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Catalogue number:
13CON016-00500
Name:
αC-conotoxin PrXA
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αC-Conotoxin PrXA (AlphaC-PrXA) was originally isolated from the venom of the fish-hunting Conus parius. αC-Conotoxin PrXA is a highly specific inhibitor of the neuromuscular nAChR. It potently antagonizes mouse muscle adult α1/β1/ε/δ nAChR subunits (IC50 = 1.8 nM) as well as fetal mouse muscle α1/β1/γ/δ nAChR subunits (IC50 = 3 nM). αC-Conotoxin PrXA competes with α-bungarotoxin for binding at the α/δ and α/γ nAChR subunit interfaces (with higher affinity however for the α/δ subunit interface). The 3D structure of αC-Conotoxin PrXA is different from other conotoxins that target nAChR and it is most similar to Waglerin-1, a nAChR blocker isolated from a snake venom. αC-Conotoxin PrXA is a useful tool for investigating the structure and physiological role of nAChRs.

Product Type:
Peptides & proteins
Storage Temp:
RT
Molecular Weight:
3541.1 Da
Reference:
Jimenez EC. (2013) Diversity of Conus peptides that target the nicotinic acetylcholine receptors. Philippine Science Letters; Jimenez EC., et al. (2007) AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists. Biochemistry.