α-conotoxin MI has been isolated from the venom of the cone snail Conus magus. This conotoxin acts on postsynaptic membranes. It binds onto and blocks nicotinic acetylcholine receptors (nAChR). α-conotoxin MI blocks mammalian nAChR composed of α1/δ subunits with high potency and α1/γ with low potency.
Peptides & proteins
alpha conotoxin MI
Jacobsen, R. B., et al. (1999) Biochemistry; Gray, W. R., et al. (1983) J Biol Chem; McIntosh, M., et al. (1982) Arch Biochem Biophys